Sox (Sex-determining region Y-box) proteins are a family of transcription factors that play critical roles in cell fate determination, differentiation, and development. They are characterized by the presence of a high-mobility group (HMG) domain, which allows them to bind to DNA and regulate the expression of target genes. HIF-2α (Hypoxia-inducible factor 2 alpha) is a transcription factor that regulates the cellular response to low oxygen levels (hypoxia). It plays a key role in the adaptation of cells to low oxygen conditions by promoting the expression of genes involved in angiogenesis, erythropoiesis, and glucose metabolism. Research on the interaction between Sox proteins and HIF-2α has revealed that Sox proteins can directly interact with and regulate the activity of HIF-2α, thereby influencing cellular responses to hypoxia. This interaction has been implicated in various physiological and pathological processes, including cancer progression, stem cell maintenance, and cellular metabolism. Overall, research in this area aims to elucidate the molecular mechanisms underlying the crosstalk between Sox proteins and HIF-2α and how this interaction regulates cellular responses to hypoxia and other environmental stimuli.